Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65)

T cell recognition of autoantigens is critical to progressive immune-mediated destruction of islet cells, which leads to autoimmune diabetes. We identified a naturally presented autoantigen from the human islet antigen glutamic acid decarboxylase, 65-kDa isoform (GAD65), by using a combination of ch...

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Detalhes bibliográficos
Main Authors: Nepom, Gerald T., Lippolis, John D., White, Forest M., Masewicz, Susan, Marto, Jarrod A., Herman, Andrew, Luckey, C. John, Falk, Ben, Shabanowitz, Jeffrey, Hunt, Donald F., Engelhard, Victor H., Nepom, Barbara S.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC29331/
https://ncbi.nlm.nih.gov/pubmed/11172025
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