Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65)

T cell recognition of autoantigens is critical to progressive immune-mediated destruction of islet cells, which leads to autoimmune diabetes. We identified a naturally presented autoantigen from the human islet antigen glutamic acid decarboxylase, 65-kDa isoform (GAD65), by using a combination of ch...

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Main Authors: Nepom, Gerald T., Lippolis, John D., White, Forest M., Masewicz, Susan, Marto, Jarrod A., Herman, Andrew, Luckey, C. John, Falk, Ben, Shabanowitz, Jeffrey, Hunt, Donald F., Engelhard, Victor H., Nepom, Barbara S.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2001
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC29331/
https://ncbi.nlm.nih.gov/pubmed/11172025
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