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Existence of a non-canonical state of iron-bound transferrin at endosomal pH revealed by hydrogen exchange and mass spectrometry
Transferrin is an enigmatic metalloprotein, which exhibits a profound conformational change upon binding of ferric ion and a synergistic anion (oxalate or carbonate). While the apo- and holo-forms of the protein have well-defined and stable conformations termed “open” and “closed,” certain aspects o...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2933096/ https://ncbi.nlm.nih.gov/pubmed/19324057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.03.044 |
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