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Cell-based immunotherapy of prion diseases by adoptive transfer of antigen-loaded dendritic cells or antigen-primed CD(4+) T lymphocytes

Prion diseases are neurodegenerative conditions caused by the transconformation of a normal host glycoprotein, the cellular prion protein (PrPc) into a neurotoxic, self-aggregating conformer (PrPSc). TSEs are ineluctably fatal and no treatment is yet available. In principle, prion diseases could be...

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Bibliografske podrobnosti
Main Authors: Carnaud, Claude, Bachy, Véronique
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933053/
https://ncbi.nlm.nih.gov/pubmed/20622507
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