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CD8+ T Cell Priming by Dendritic Cell Vaccines Requires Antigen Transfer to Endogenous Antigen Presenting Cells

BACKGROUND: Immunotherapeutic strategies to stimulate anti-tumor immunity are promising approaches for cancer treatment. A major barrier to their success is the immunosuppressive microenvironment of tumors, which inhibits the functions of endogenous dendritic cells (DCs) that are necessary for the g...

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Autors principals: Yewdall, Alice W., Drutman, Scott B., Jinwala, Felecia, Bahjat, Keith S., Bhardwaj, Nina
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886840/
https://ncbi.nlm.nih.gov/pubmed/20585396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011144
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