Progressive accumulation of amyloid-β oligomers in Alzheimer’s disease and APP transgenic mice is accompanied by selective alterations in synaptic scaffold proteins

The cognitive impairment in patients with Alzheimer’s disease is closely associated with synaptic loss in the neocortex and limbic system. Although the neurotoxic effects of aggregated amyloid-β (Aβ) oligomers in Alzheimer’s disease have been widely studied in experimental models, less is known abou...

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Détails bibliographiques
Auteurs principaux: Pham, Emiley, Crews, Leslie, Ubhi, Kiren, Hansen, Lawrence, Adame, Anthony, Cartier, Anna, Salmon, David, Galasko, Douglas, Michael, Sarah, Savas, Jeffrey N., Yates, John R., Glabe, Charles, Masliah, Eliezer
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933033/
https://ncbi.nlm.nih.gov/pubmed/20573181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2010.07719.x
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