Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit

The mammalian 26S proteasome is a 2500 kDa multi-catalytic complex involved in intracellular protein degradation. We describe the synthesis and properties of a novel series of non-covalent di-peptide inhibitors of the proteasome used on a capped tri-peptide that was first identified by high-throughp...

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Detalhes bibliográficos
Main Authors: Blackburn, Christopher, Gigstad, Kenneth M., Hales, Paul, Garcia, Khristofer, Jones, Matthew, Bruzzese, Frank J., Barrett, Cynthia, Liu, Jane X., Soucy, Teresa A., Sappal, Darshan S., Bump, Nancy, Olhava, Edward J., Fleming, Paul, Dick, Lawrence R., Tsu, Christopher, Sintchak, Michael D., Blank, Jonathan L.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933030/
https://ncbi.nlm.nih.gov/pubmed/20632995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20100383
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