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Distinct Specificities of Mycobacterium tuberculosis and Mammalian Proteasomes for N-Acetyl Tripeptide Substrates

The proteasome of Mycobacterium tuberculosis (Mtb) is a validated and drug-treatable target for therapeutics. To lay ground-work for developing peptide-based inhibitors with a useful degree of selectivity for the Mtb proteasome over those of the host, we used a library of 5,920 N-acetyl tripeptide-a...

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Detalhes bibliográficos
Main Authors: Lin, Gang, Tsu, Christopher, Dick, Lawrence, Zhou, Xi K., Nathan, Carl
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590702/
https://ncbi.nlm.nih.gov/pubmed/18829465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805324200
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