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Homocitrate synthase connects amino acid metabolism to chromatin functions through Esa1 and DNA damage
The enzyme homocitrate synthase (HCS) catalyzes the first step in lysine biosynthesis, and early biochemical data placed it in the cytoplasm or mitochondria, where most amino acid synthesis occurs. It was therefore surprising when refined fractionation techniques and specific immunoreagents clearly...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2932972/ https://ncbi.nlm.nih.gov/pubmed/20810648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1935910 |
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