Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines

The aged canine is a higher animal model that naturally accumulates β-amyloid (Aβ) and shows age-related cognitive decline. However, profiles of Aβ accumulation in different species (40 vs. 42), its assembly states, and Aβ precursor protein (APP) processing as a function of age remain unexplored. In...

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Autori principali: Pop, Viorela, Head, Elizabeth, Berchtold, Nicole C., Glabe, Charles G., Studzinski, Christa M., Weidner, Adam M., Murphy, M. Paul, Cotman, Carl W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932860/
https://ncbi.nlm.nih.gov/pubmed/20434811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2010.02.008
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