Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis

Our understanding of primary biliary cirrhosis (PBC) has been significantly enhanced by the rigorous dissection of the multilineage T and B cell response against the immunodominant mitochondrial autoantigen, the E2 component of the pyruvate dehydrogenase complex (PDC-E2). PDC-E2 is a ubiquitous prot...

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Main Authors: Lleo, Ana, Bowlus, Christopher L., Yang, Guo-Xiang, Invernizzi, Pietro, Podda, Mauro, Van de Water, Judy, Ansari, Aftab A., Coppel, Ross L., Worman, Howard J., Gores, Gregory J., Gershwin, M. Eric
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932809/
https://ncbi.nlm.nih.gov/pubmed/20568301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23783
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