Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses

Glutamate is the major excitatory neurotransmitter in the brain. The NMDA subtype of glutamate receptors (NMDAR) is known to mediate many physiological neural functions. However, excessive activation of NMDARs contributes to neuronal damage in various acute and chronic neurological disorders. To avo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Xia, Peng, Chen, Huei-sheng Vincent, Zhang, Dongxian, Lipton, Stuart A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2010
Schlagworte:
Brief Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932667/
https://ncbi.nlm.nih.gov/pubmed/20720132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2488-10.2010
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