Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses

Glutamate is the major excitatory neurotransmitter in the brain. The NMDA subtype of glutamate receptors (NMDAR) is known to mediate many physiological neural functions. However, excessive activation of NMDARs contributes to neuronal damage in various acute and chronic neurological disorders. To avo...

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Detalles Bibliográficos
Autores principales: Xia, Peng, Chen, Huei-sheng Vincent, Zhang, Dongxian, Lipton, Stuart A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2010
Materias:
Brief Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932667/
https://ncbi.nlm.nih.gov/pubmed/20720132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2488-10.2010
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