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A family of diiron monooxygenases catalyzing amino acid beta-hydroxylation in antibiotic biosynthesis

The biosynthesis of chloramphenicol requires a β-hydroxylation tailoring reaction of the precursor L-p-aminophenylalanine (L-PAPA). Here, it is shown that this reaction is catalyzed by the enzyme CmlA from an operon containing the genes for biosynthesis of L-PAPA and the nonribosomal peptide synthet...

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Main Authors: Makris, Thomas M., Chakrabarti, Mrinmoy, Münck, Eckard, Lipscomb, John D.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932612/
https://ncbi.nlm.nih.gov/pubmed/20713732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007953107
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