Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis

Toll-like receptors (TLRs) are innate immune receptors that have recently emerged as regulators of neuronal survival and developmental neuroplasticity. Adult TLR3-deficient mice exhibited enhanced hippocampus-dependent working memory in the Morris water maze, novel object recognition, and contextual...

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Huvudupphovsmän: Okun, Eitan, Griffioen, Kathleen, Barak, Boaz, Roberts, Nicholas J., Castro, Kamilah, Pita, Mario A., Cheng, Aiwu, Mughal, Mohamed R., Wan, Ruiqian, Ashery, Uri, Mattson, Mark P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2010
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932590/
https://ncbi.nlm.nih.gov/pubmed/20713712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005807107
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