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Deficiency of Toll-like receptors 2, 3 or 4 extends life expectancy in Huntington’s disease mice

Huntington’s disease (HD), an autosomal dominant neurodegenerative disorder characterized by progressive striatal and cortical atrophy, has been strongly linked with neuroinflammation. Toll-like receptors, a family of innate immune receptors, are a major pathway for neuroinflammation with pleiotropi...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Heliyon
Main Authors: Griffioen, Kathleen, Mattson, Mark P., Okun, Eitan
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857515/
https://ncbi.nlm.nih.gov/pubmed/29560427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2018.e00508
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