Uterine FK506-binding protein 52 (FKBP52)–peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress

Immunophilin FK506-binding protein 52 (FKBP52) is a cochaperone that binds to the progesterone receptor (PR) to optimize progesterone (P(4))-PR signaling. We recently showed that Fkbp52-deficient (Fkbp52(−/−)) mice have reduced uterine PR responsiveness and implantation failure which is rescued by e...

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Autori principali: Hirota, Yasushi, Acar, Nuray, Tranguch, Susanne, Burnum, Kristin E., Xie, Huirong, Kodama, Ako, Osuga, Yutaka, Ustunel, Ismail, Friedman, David B., Caprioli, Richard M., Daikoku, Takiko, Dey, Sudhansu K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932576/
https://ncbi.nlm.nih.gov/pubmed/20713718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009324107
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