The B cell mutator AID promotes B lymphoid blast crisis and drug-resistance in chronic myeloid leukemia

Chronic myeloid leukemia (CML) is induced by BCR-ABL1 and can be effectively treated for many years with Imatinib until leukemia cells acquire drug resistance through BCR-ABL1 mutations and progress into fatal B lymphoid blast crisis (LBC). Despite its clinical significance, the mechanism of progres...

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Bibliografiske detaljer
Main Authors: Klemm, Lars, Duy, Cihangir, Iacobucci, Ilaria, Kuchen, Stefan, von Levetzow, Gregor, Feldhahn, Niklas, Henke, Nadine, Li, Zhiyu, Hoffmann, Thomas K., Kim, Yong-mi, Hofmann, Wolf-Karsten, Jumaa, Hassan, Groffen, John, Heisterkamp, Nora, Martinelli, Giovanni, Lieber, Michael R, Casellas, Rafael, Müschen, Markus
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931825/
https://ncbi.nlm.nih.gov/pubmed/19732723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.07.030
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