Refolding the Engrailed Homeodomain: Structural Basis for the Accumulation of a Folding Intermediate

The ultrafast folding pathway of the engrailed homeodomain has been exceptionally well characterized by experiment and simulation. Helices II and III of the three-helix bundle protein form the native helix-turn-helix motif as an on-pathway intermediate within a few microseconds. The slow step is the...

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Bibliographic Details
Main Authors: McCully, Michelle E., Beck, David A.C., Fersht, Alan R., Daggett, Valerie
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2010
Subjects:
Protein
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931720/
https://ncbi.nlm.nih.gov/pubmed/20816076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.06.040
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