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Promiscuous contacts and heightened dynamics increase thermostability in an engineered variant of the engrailed homeodomain
A thermostabilized variant (UVF) of the engrailed homeodomain (EnHD) was previously engineered by Mayo and co-workers. The melting temperature of the non-natural, designed protein is 50°C higher than the natural wild-type protein (>99 vs. 52°C), and the two proteins share 22% sequence identity. W...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3522382/ https://ncbi.nlm.nih.gov/pubmed/23012442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzs063 |
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