The Ubiquitin Modifying Enayme A20 Restricts B cell Survival and Prevents Autoimmunity

A20 is a ubiquitin modifying enzyme that restricts NF-κB signals and protects cells against tumor necrosis factor (TNF) induced programmed cell death. Given recent data linking A20 (TNFAIP3) with human B cell lymphomas and systemic lupus erythematosus (SLE), we have generated mice bearing a floxed a...

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Autors principals: Tavares, Rita M., Turer, Emre E., Liu, Chih L., Advincula, Rommel, Scapini, Patrizia, Rhee, Lesley, Barrera, Julio, Lowell, Clifford A., Utz, Paul J., Malynn, Barbara A., Ma, Averil
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931361/
https://ncbi.nlm.nih.gov/pubmed/20705491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.07.017
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