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The Ubiquitin Modifying Enayme A20 Restricts B cell Survival and Prevents Autoimmunity
A20 is a ubiquitin modifying enzyme that restricts NF-κB signals and protects cells against tumor necrosis factor (TNF) induced programmed cell death. Given recent data linking A20 (TNFAIP3) with human B cell lymphomas and systemic lupus erythematosus (SLE), we have generated mice bearing a floxed a...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2931361/ https://ncbi.nlm.nih.gov/pubmed/20705491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.07.017 |
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