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BimEL as a possible molecular link between proteasome dysfunction and cell death induced by mutant huntingtin
Huntington’s disease (HD) is a devastating neurodegenerative disorder caused by an expanded polyglutamine repeat within the N-terminus of the huntingtin protein. It is characterized by a selective loss of medium spiny neurons in the striatum. It has been suggested that impaired proteasome function a...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2931320/ https://ncbi.nlm.nih.gov/pubmed/20497470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2010.07215.x |
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