Widespread genomic breaks from activation-induced cytidine deaminase are prevented by homologous recombination

Activation induced cytidine deaminase (AID) is required for somatic hypermutation and immunoglobulin class switching in activated B cells. Because AID possesses no known target site specificity, there have been efforts to identify non-immunoglobulin AID targets. We show that AID acts promiscuously,...

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Main Authors: Hasham, Muneer G., Donghia, Nina M., Coffey, Eliot, Maynard, Jane, Snow, Kathy J., Ames, Jacquelyn, Wilpan, Robert Y., He, Yishu, King, Benjamin L., Mills, Kevin D.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930818/
https://ncbi.nlm.nih.gov/pubmed/20657597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1909
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