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mTORC1 Links Protein Quality and Quantity Control by Sensing Chaperone Availability
Balanced protein synthesis and degradation are crucial for proper cellular function. Protein synthesis is tightly coupled to energy status and nutrient levels by the mammalian target of rapamycin complex 1 (mTORC1). Quality of newly synthesized polypeptides is maintained by the molecular chaperone a...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2930736/ https://ncbi.nlm.nih.gov/pubmed/20605781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.120295 |
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