Heparan Sulfate Domain Organization and Sulfation Modulate FGF-induced Cell Signaling

Heparan sulfates (HSs) modulate various developmental and homeostatic processes by binding to protein ligands. We have evaluated the structural characteristics of porcine HS in cellular signaling induced by basic fibroblast growth factor (FGF2), using CHO745 cells devoid of endogenous glycosaminogly...

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Bibliographic Details
Main Authors: Jastrebova, Nadja, Vanwildemeersch, Maarten, Lindahl, Ulf, Spillmann, Dorothe
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930683/
https://ncbi.nlm.nih.gov/pubmed/20576609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.093542
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