ArPIKfyve Regulates Sac3 Protein Abundance and Turnover: DISRUPTION OF THE MECHANISM BY Sac3(I41T) MUTATION CAUSING CHARCOT-MARIE-TOOTH 4J DISORDER

The mammalian phosphatidylinositol (3,5)-bisphosphate (PtdIns(3,5)P(2)) phosphatase Sac3 and ArPIKfyve, the associated regulator of the PtdIns3P-5 kinase PIKfyve, form a stable binary complex that associates with PIKfyve in a ternary complex to increase PtdIns(3,5)P(2) production. Whether the ArPIKf...

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Detalhes bibliográficos
Main Authors: Ikonomov, Ognian C., Sbrissa, Diego, Fligger, Jason, Delvecchio, Khortnal, Shisheva, Assia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930674/
https://ncbi.nlm.nih.gov/pubmed/20630877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.154658
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