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Purkinje Cells from RyR2 Mutant Mice are Highly Arrhythmogenic but Responsive to Targeted Therapy
RATIONALE: The Purkinje fiber network has been proposed as the source of arrhythmogenic Ca(2+) release events in catecholaminergic polymorphic ventricular tachycardia (CPVT) yet evidence supporting this mechanism at the cellular level is lacking. OBJECTIVE: We sought to determine the frequency and s...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2930621/ https://ncbi.nlm.nih.gov/pubmed/20595652 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.221481 |
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