The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear

BACKGROUND: The planar cell polarity (PCP) signalling pathway is fundamental to a number of key developmental events, including initiation of neural tube closure. Disruption of the PCP pathway causes the severe neural tube defect of craniorachischisis, in which almost the entire brain and spinal cor...

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Main Authors: Paudyal, Anju, Damrau, Christine, Patterson, Victoria L, Ermakov, Alexander, Formstone, Caroline, Lalanne, Zuzanna, Wells, Sara, Lu, Xiaowei, Norris, Dominic P, Dean, Charlotte H, Henderson, Deborah J, Murdoch, Jennifer N
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930600/
https://ncbi.nlm.nih.gov/pubmed/20704721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-10-87
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