Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners

Vitamin K epoxide reductase (VKOR) sustains blood coagulation by reducing vitamin K epoxide to the hydroquinone, an essential cofactor for the γ-glutamyl carboxylation of many clotting factors. The physiological redox partner of VKOR remains uncertain, but is likely a thioredoxin-like protein. Here,...

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Bibliographic Details
Main Authors: Schulman, Sol, Wang, Belinda, Li, Weikai, Rapoport, Tom A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930587/
https://ncbi.nlm.nih.gov/pubmed/20696932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009972107
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