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Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis

Nuclear factor of activated T cells (NFAT) proteins are a group of Ca(2+)-regulated transcription factors residing in the cytoplasm of resting cells. Dephosphorylation by calcineurin results in nuclear translocation of NFAT and subsequent expression of target genes; rephosphorylation by kinases, inc...

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Detalhes bibliográficos
Main Authors: Ghosh, Srimoyee, Koralov, Sergei B., Stevanovic, Irena, Sundrud, Mark S., Sasaki, Yoshiteru, Rajewsky, Klaus, Rao, Anjana, Müller, Martin R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930568/
https://ncbi.nlm.nih.gov/pubmed/20696888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009193107
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