Pseudovirion Particles Bearing Native HIV Envelope Trimers Facilitate a Novel Method for Generating Human Neutralizing Monoclonal Antibodies against HIV

Monomeric HIV envelope vaccines fail to elicit broadly neutralizing antibodies or to protect against infection. Neutralizing antibodies against HIV bind to native, functionally active Env trimers on the virion surface. Gag-Env pseudovirions recapitulate the native trimer, and could serve as an effec...

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Detalhes bibliográficos
Main Authors: Hicar, Mark D., Chen, Xuemin, Briney, Bryan, Hammonds, Jason, Wang, Jaang-Jiun, Kalams, Spyros, Spearman, Paul W., Crowe, James E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930513/
https://ncbi.nlm.nih.gov/pubmed/20531016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e3181dc98a3
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