Pseudovirion Particles Bearing Native HIV Envelope Trimers Facilitate a Novel Method for Generating Human Neutralizing Monoclonal Antibodies against HIV

Monomeric HIV envelope vaccines fail to elicit broadly neutralizing antibodies or to protect against infection. Neutralizing antibodies against HIV bind to native, functionally active Env trimers on the virion surface. Gag-Env pseudovirions recapitulate the native trimer, and could serve as an effec...

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Main Authors: Hicar, Mark D., Chen, Xuemin, Briney, Bryan, Hammonds, Jason, Wang, Jaang-Jiun, Kalams, Spyros, Spearman, Paul W., Crowe, James E.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930513/
https://ncbi.nlm.nih.gov/pubmed/20531016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e3181dc98a3
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