Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

Inhibitory receptors play a crucial role in regulating CD8 T-cell function during chronic viral infection. T-cell Ig- and mucin-domain–containing molecule–3 (Tim-3) is well known to negatively regulate T-cell responses, but its role in CD8 T-cell exhaustion during chronic infection in vivo remains u...

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Bibliographic Details
Main Authors: Jin, Hyun-Tak, Anderson, Ana C., Tan, Wendy G., West, Erin E., Ha, Sang-Jun, Araki, Koichi, Freeman, Gordon J., Kuchroo, Vijay K., Ahmed, Rafi
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930455/
https://ncbi.nlm.nih.gov/pubmed/20679213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009731107
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