Charge interactions can dominate the dimensions of intrinsically disordered proteins

Many eukaryotic proteins are disordered under physiological conditions, and fold into ordered structures only on binding to their cellular targets. Such intrinsically disordered proteins (IDPs) often contain a large fraction of charged amino acids. Here, we use single-molecule Förster resonance ener...

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Bibliographic Details
Main Authors: Müller-Späth, Sonja, Soranno, Andrea, Hirschfeld, Verena, Hofmann, Hagen, Rüegger, Stefan, Reymond, Luc, Nettels, Daniel, Schuler, Benjamin
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930438/
https://ncbi.nlm.nih.gov/pubmed/20639465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001743107
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