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Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair
Histone deacetylase inhibitors (HDACi) developed as anti-cancer agents have a high degree of selectivity for killing cancer cells. HDACi induce acetylation of histones and nonhistone proteins, which affect gene expression, cell cycle progression, cell migration, and cell death. The mechanism of the...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2930422/ https://ncbi.nlm.nih.gov/pubmed/20679231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008522107 |
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