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Crystal structure of human adenovirus at 3.5 Å resolution

Rational development of adenovirus vectors for therapeutic gene transfer is hampered by the lack of accurate structural information. Here we report the X-ray structure at 3.5 Å resolution of the 150 megadalton adenovirus capsid containing nearly 1 million amino acids. We describe interactions betwee...

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Detalhes bibliográficos
Main Authors: Reddy, Vijay S., Natchiar, S. Kundhavai, Stewart, Phoebe L., Nemerow, Glen R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929978/
https://ncbi.nlm.nih.gov/pubmed/20798318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1187292
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