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cAMP-activated Ca(2+) signaling is required for CFTR-mediated serous cell fluid secretion in porcine and human airways
Cystic fibrosis (CF), which is caused by mutations in CFTR, affects many tissues, including the lung. Submucosal gland serous acinar cells are primary sites of fluid secretion and CFTR expression in the lung. Absence of CFTR in these cells may contribute to CF lung pathogenesis by disrupting fluid s...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2929731/ https://ncbi.nlm.nih.gov/pubmed/20739756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42992 |
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