Reconstruction of the complete human cytomegalovirus genome in a BAC reveals RL13 to be a potent inhibitor of replication

Human cytomegalovirus (HCMV) in clinical material cannot replicate efficiently in vitro until it has adapted by mutation. Consequently, wild-type HCMV differ fundamentally from the passaged strains used for research. To generate a genetically intact source of HCMV, we cloned strain Merlin into a sel...

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Main Authors: Stanton, Richard J., Baluchova, Katarina, Dargan, Derrick J., Cunningham, Charles, Sheehy, Orla, Seirafian, Sepehr, McSharry, Brian P., Neale, M. Lynne, Davies, James A., Tomasec, Peter, Davison, Andrew J., Wilkinson, Gavin W.G.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2010
主題:
Technical Advance
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929729/
https://ncbi.nlm.nih.gov/pubmed/20679731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42955
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