Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice

The hallmark of human Mycobacterium tuberculosis infection is the presence of lung granulomas. Lung granulomas can have different phenotypes, with caseous necrosis and hypoxia present within these structures during active tuberculosis. Production of NO by the inducible host enzyme NOS2 is a key anti...

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Detalhes bibliográficos
Main Authors: Reece, Stephen T., Loddenkemper, Christoph, Askew, David J., Zedler, Ulrike, Schommer-Leitner, Sandra, Stein, Maik, Mir, Fayaz Ahmad, Dorhoi, Anca, Mollenkopf, Hans-Joachim, Silverman, Gary A., Kaufmann, Stefan H.E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929725/
https://ncbi.nlm.nih.gov/pubmed/20679732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42796
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