Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice

The hallmark of human Mycobacterium tuberculosis infection is the presence of lung granulomas. Lung granulomas can have different phenotypes, with caseous necrosis and hypoxia present within these structures during active tuberculosis. Production of NO by the inducible host enzyme NOS2 is a key anti...

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Main Authors: Reece, Stephen T., Loddenkemper, Christoph, Askew, David J., Zedler, Ulrike, Schommer-Leitner, Sandra, Stein, Maik, Mir, Fayaz Ahmad, Dorhoi, Anca, Mollenkopf, Hans-Joachim, Silverman, Gary A., Kaufmann, Stefan H.E.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929725/
https://ncbi.nlm.nih.gov/pubmed/20679732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42796
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