Silencing Nogo-A Promotes Functional Recovery in Demyelinating Disease

OBJECTIVE: To determine if suppressing Nogo-A, an axonal inhibitory protein, will promote functional recovery in a murine model of multiple sclerosis (MS). METHODS: A small interfering RNA was developed to specifically suppress Nogo-A (siRNA-NogoA). The siRNA-NogoA silencing effect was evaluated in...

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Detalhes bibliográficos
Main Authors: Yang, Yuhong, Liu, Yue, Wei, Ping, Peng, Haiyan, Winger, Ryan, Hussain, Rehana Z., Ben, Li-Hong, Cravens, Petra D., Gocke, Anne R., Puttaparthi, Krishna, Racke, Michael K., McTigue, Dana M., Lovett-Racke, Amy E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929680/
https://ncbi.nlm.nih.gov/pubmed/20437585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.21935
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