Pharmacological prion protein silencing accelerates central nervous system autoimmune disease via T cell receptor signalling

The primary biological function of the endogenous cellular prion protein has remained unclear. We investigated its biological function in the generation of cellular immune responses using cellular prion protein gene-specific small interfering ribonucleic acid in vivo and in vitro. Our results were c...

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Main Authors: Hu, Wei, Nessler, Stefan, Hemmer, Bernhard, Eagar, Todd N., Kane, Lawrence P., Leliveld, S. Rutger, Müller-Schiffmann, Andreas, Gocke, Anne R., Lovett-Racke, Amy, Ben, Li-Hong, Hussain, Rehana Z., Breil, Andreas, Elliott, Jeffrey L., Puttaparthi, Krishna, Cravens, Petra D., Singh, Mahendra P., Petsch, Benjamin, Stitz, Lothar, Racke, Michael K., Korth, Carsten, Stüve, Olaf
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822628/
https://ncbi.nlm.nih.gov/pubmed/20145049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awp298
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