A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I Interferons

Neutrophil-specific genes are abundant in PBMC microarrays from lupus patients due to presence of low density granulocytes (LDGs) in mononuclear cell fractions. The functionality and pathogenicity of these LDGs have not been characterized. We developed a technique to purify LDGs from lupus PBMCs and...

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Главные авторы: Denny, Michael F., Yalavarthi, Srilakshmi, Zhao, Wenpu, Thacker, Seth G., Anderson, Marc, Sandy, Ashley R., McCune, W. Joseph, Kaplan, Mariana J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929645/
https://ncbi.nlm.nih.gov/pubmed/20164424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902199
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