Netting neutrophils induce endothelial damage, infiltrate tissues and expose immunostimulatory molecules in systemic lupus erythematosus

An abnormal neutrophil subset has been identified in the PBMC fractions from lupus patients. We have proposed that these “low density granulocytes” (LDGs) play an important role in lupus pathogenesis by damaging endothelial cells and synthesizing increased levels of proinflammatory cytokines and typ...

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Auteurs principaux: Villanueva, Eneida, Yalavarthi, Srilakshmi, Berthier, Celine C., Hodgin, Jeffrey B., Khandpur, Ritika, Lin, Andrew M., Rubin, Cory J., Zhao, Wenpu, Olsen, Stephen H., Klinker, Matthew, Shealy, David, Denny, Michael F., Plumas, Joel, Chaperot, Laurence, Kretzler, Matthias, Bruce, Allen T., Kaplan, Mariana J.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119769/
https://ncbi.nlm.nih.gov/pubmed/21613614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100450
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