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STAT3 activation of miR-21 and miR-181b-1, via PTEN and CYLD, are part of the epigenetic switch linking inflammation to cancer
A transient inflammatory signal can initiate an epigenetic switch from non-transformed to cancer cells via a positive feedback loop involving NF-κB, Lin28, let-7, and IL6. We identify differentially regulated microRNAs important for this switch, and putative transcription factor binding sites in the...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2929389/ https://ncbi.nlm.nih.gov/pubmed/20797623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.07.023 |
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