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STAT3 activation of miR-21 and miR-181b-1, via PTEN and CYLD, are part of the epigenetic switch linking inflammation to cancer

A transient inflammatory signal can initiate an epigenetic switch from non-transformed to cancer cells via a positive feedback loop involving NF-κB, Lin28, let-7, and IL6. We identify differentially regulated microRNAs important for this switch, and putative transcription factor binding sites in the...

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Detalhes bibliográficos
Main Authors: Iliopoulos, Dimitrios, Jaeger, Savina A., Hirsch, Heather A., Bulyk, Martha L., Struhl, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929389/
https://ncbi.nlm.nih.gov/pubmed/20797623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.07.023
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