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Understanding resistance to EGFR inhibitors—impact on future treatment strategies
EGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. Following ligand binding, EGFR stimulates downstream cell signaling cascades that influence cell proliferation, apoptosis, migration, survival and complex processes, including angiogenesis and tumorigenesis. EGFR...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2929287/ https://ncbi.nlm.nih.gov/pubmed/20551942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrclinonc.2010.97 |
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