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p38γ Mitogen-activated Protein Kinase Suppresses Chondrocyte Production of MMP-13 in Response to Catabolic Stimulation

OBJECTIVE: The signaling protein p38 mitogen-activated protein kinase is required for inflammatory signaling in chondrocytes that regulates MMP production. We sought to determine the role of specific p38 isoforms in chondrocyte catabolic signaling in response to IL-1β and fibronectin fragments. METH...

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Hlavní autoři: Long, D.L., Loeser, R.F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929282/
https://ncbi.nlm.nih.gov/pubmed/20633667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2010.05.016
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