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Total Synthesis of Fostriecin: Via a Regio- and Stereoselective Polyene Hydration, Oxidation and Hydroboration Sequence
[Image: see text] A total synthesis of the fostriecin has been achieved in 24 steps from enyne 11. The lactone moiety was installed by a Leighton allylation and Grubbs ring-closing metathesis (RCM) reaction. The highly reactive Z,Z,E-triene moiety was installed via a late stage Suzuki-Miyaura cross...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2929272/ https://ncbi.nlm.nih.gov/pubmed/20687585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol101340n |
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