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CREB Inhibits AP-2α Expression to Regulate the Malignant Phenotype of Melanoma

BACKGROUND: The loss of AP-2α and increased activity of cAMP-responsive element binding (CREB) protein are two hallmarks of malignant progression of cutaneous melanoma. However, the molecular mechanism responsible for the loss of AP-2α during melanoma progression remains unknown. METHODOLOGY/PRINCIP...

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Detalhes bibliográficos
Main Authors: Melnikova, Vladislava O., Dobroff, Andrey S., Zigler, Maya, Villares, Gabriel J., Braeuer, Russell R., Wang, Hua, Huang, Li, Bar-Eli, Menashe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929203/
https://ncbi.nlm.nih.gov/pubmed/20805990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012452
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