Suppression of uPA and uPAR Attenuates Angiogenin Mediated Angiogenesis in Endothelial and Glioblastoma Cell Lines

BACKGROUND: In our earlier reports, we showed that downregulation of uPA and uPAR inhibited glioma tumor angiogenesis in SNB19 cells, and intraperitoneal injection of a hairpin shRNA expressing plasmid targeting uPA and uPAR inhibited angiogenesis in nude mice. The exact mechanism by which inhibitio...

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Autores principales: Raghu, Hari, Lakka, Sajani S., Gondi, Christopher S., Mohanam, Sanjeeva, Dinh, Dzung H., Gujrati, Meena, Rao, Jasti S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929192/
https://ncbi.nlm.nih.gov/pubmed/20805979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012458
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