Sindbis virus usurps the cellular HuR protein to stabilize its transcripts and promote productive infections in mammalian and mosquito cells

The mechanisms utilized by viruses to protect their transcripts from the cellular RNA decay machinery, as well as the biological relevance of this protection, are largely unknown. We demonstrate that Sindbis virus uses U-rich 3’ UTR sequences in its RNAs to recruit the cellular HuR protein during in...

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Bibliographic Details
Main Authors: Sokoloski, Kevin J., Dickson, Alexa M., Chaskey, Emily L., Garneau, Nicole L., Wilusz, Carol J., Wilusz, Jeffrey
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929003/
https://ncbi.nlm.nih.gov/pubmed/20709296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2010.07.003
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